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October 2016

Critical Period-Like Plasticity in the Adult Brain, Eero Castren, MD/PhD

October 6, 2016 @ 1:25 pm - 1:50 pm

Eero Castren, MD/PhD, Director, Neuroscience Center, University of Helsinki, Finland -- Experience-driven neuronal plasticity shapes neuronal networks during development, but plasticity is reduced in adult brain after the closure of early postnatal critical periods.  We have found that pharmacological treatment with the antidepressant fluoxetine reactivates a critical period-like plasticity in the adult rodent brain.  When this drug treatment is combined with environmental experiences or rehabilitation, plastic networks can be precisely tuned towards more optimal functionality.  Our current research is elucidating…

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Clinician Panel: Jeff Elias, MD; Erin Foff, MD/PhD; Thor Willy Ruud Hansen, MD/PhD; Anita Kablinger, MD

October 6, 2016 @ 1:50 pm - 2:50 pm

Presenters will share a clinical perspective on precision neuroscience from their experiences in clinical practice.

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October 6, 2016 @ 2:50 pm - 3:20 pm
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Brain-Computer Interfaces for Basic Science, Byron Yu, PhD

October 6, 2016 @ 3:20 pm - 3:45 pm

Byron Yu, PhD, Associate Professor of Electrical and Computer Engineering and Biomedical Engineering, Carnegie Mellon University

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The Molecular Control of Synaptic Plasticity and Its Importance for Precision Neuroscience, Clive Bramham, MD/PhD

October 6, 2016 @ 3:45 pm - 4:10 pm

Clive Bramham, MD/PhD, Professor of Neuroscience, Department of Biomedicine and KG Jebsen Centre for Neuropsychiatric Disorders, University of Bergen, Bergen, Norway -- The adaptive capacity of the brain depends on synaptic plasticity – the ability of a synapse to change in strength in response to use or disuse. Plasticity in neural circuits shapes emotional responses, cognitive flexibility, and underlies memory formation. Aberrant synaptic plasticity likely impacts human cognition in brain disorders such as autism, schizophrenia, and Alzheimer’s disease. I will…

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Matricryptins Trigger Inhibitory Synapse Formation in the Developing Neocortex, Mike Fox, PhD

October 6, 2016 @ 4:10 pm - 4:35 pm

Mike Fox, PhD, Associate Professor, Virginia Tech Carilion Research Institute and Director of the VTCRI Developmental and Translational Neurobiology Center -- Although inhibitory synapses comprise only ~20% of the total synapses in the mammalian cerebrum, they play essential roles in controlling neuronal activity. In fact, perturbing inhibitory synapses is associated with complex brain disorders, such as schizophrenia. Although many types of inhibitory synapses exist, these disorders have been strongly linked to defects in inhibitory synapses formed by Parvalbumin-expressing interneurons. Despite…

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Reception for Invited Guests, Hotel Roanoke Ballroom

October 6, 2016 @ 5:15 pm - 6:00 pm
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Dinner for Invited Guests, Hotel Roanoke

October 6, 2016 @ 6:15 pm - 7:30 pm
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Imaging Life at High Spatiotemporal Resolution, Eric Betzig, PhD: Talk Location – Hotel Roanoke Washington Lecture Hall

October 6, 2016 @ 7:45 pm - 8:30 pm

Eric Betzig, PhD,  2014 Nobel Laureate in Chemistry, Group Leader, Howard Hughes Medical Institute Janelia Research Campus, Ashburn, Virginia -- As our understanding of biological systems has increased, so has the complexity of our questions and the need for more advanced optical tools to answer them.  For example, there is a hundred-fold gap between the resolution of conventional optical microscopy and the scale at which molecules self-assemble to form sub-cellular structures.  Furthermore, as we attempt to peer more closely at…

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How Glutamate and GABA Became Neurotransmitters, Jon Storm-Mathisen, MD/PhD: Talk Location – Hotel Roanoke Washington Lecture Hall

October 6, 2016 @ 8:45 pm - 9:30 pm

Jon Storm-Mathisen, MD/PhD, Professor, Centre for Molecular Biology and Neuroscience, University of Oslo, Norway -- During the decades that have passed since the epileptogenic and neurotoxic properties of glutamate and the mitigating properties of GABA were first noted, neurophysiological, neurochemical and neuroanatomic discoveries have brought forward an understanding of their role as major neurotransmitters of the mammalian brain.  A deeper understanding of how individual genotypes phenotypically respond to drugs and training will allow us to design individual therapeutic pathways for…

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