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October 2016

Registration and Continental Breakfast, 2 Riverside Circle Café/Atrium

October 7, 2016 @ 8:00 am - 8:55 am

Michael Friedlander, PhD, Vice President of Health Sciences and Technology; Executive Director, Virginia Tech Carilion Research Institute; Senior Dean for Research, Virginia Tech Carilion School of Medicine

October 7, 2016 @ 8:55 am - 9:00 am

Welcome and Introduction of Speaker

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A New (Immune) Look into Neurological Disorders, Jonathan Kipnis, PhD

October 7, 2016 @ 9:00 am - 9:25 am
Jonathan Kipnis, PhD

Jonathan Kipnis, PhD, Harrison Distinguished Professor of Neuroscience; Director, Center for Brain Immunology and Glia (BIG), University of Virginia -- The central nervous system was considered to be devoid of classical lymphatic drainage. We recently challenged that paradigm by demonstrating the presence of a lymphatic vasculature in the surrounding of the brain called the meninges. We demonstrated that lymphatic vessels, expressing all the markers for lymphatic endothelial cells (LEC; i.e Lyve-1, Prox1, podoplanin, VEGFR3 and CCL21) are located along the…

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The Lactate Receptor is Important for Brain Vascularization, Linda Hildegard Bergersen, PhD

October 7, 2016 @ 9:25 am - 9:50 am
Linda Bergersen, PhD

Linda Hildegard Bergersen, PhD, Professor, Physiology, University of Oslo, Norway and Professor, Neurobiology of Aging, University of Copenhagen, Denmark

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Targeted therapy to disrupt aberrant Glutamate release from Glioma, Harald Sontheimer, PhD

October 7, 2016 @ 9:50 am - 10:15 am
Harald Sontheimer, PhD

Harald Sontheimer, PhD, Professor/Director, of the VTCRI Center for Glial Biology in Health, Disease and Cancer; I.D. Wilson Chair, Executive Director, School of Neuroscience, Virginia Tech College of Science

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Break

October 7, 2016 @ 10:15 am - 10:45 am

The ‘Interactome’ of HIV and Opiate Abuse: Glia as Architects of Amplified CNS Damage, Pamela Knapp, PhD

October 7, 2016 @ 10:45 am - 11:10 am
Pamela Knapp, PhD

Pamela Knapp, PhD, Professor of Anatomy and Neurobiology, Virginia Commonwealth School of Medicine -- HIV and injection opiate abuse have been described as interlinked epidemics. Even in HIV+ patients receiving anti-retroviral treatments that dramatically reduce the peripheral viral load, those with current or past opiate use exhibit higher rates of CNS dysfunction, including both motor and cognitive deficits. Glial cells are involved in the pathologies associated with HIV and opiate abuse individually, and both astroglia and microglia appear to be…

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Identifying Precise Pharmacological Targets for Aberrant Neuronal Cell Cycle Re-entry in Alzheimer’s Disease, John Lazo, PhD

October 7, 2016 @ 11:10 am - 11:35 am
John Lazo, PhD

John Lazo, PhD, Harrison Distinguished Professor, Departments of Pharmacology and Chemistry; Director, Fiske Drug Discovery Lab;  University of Virginia -- We are investigating the hypothesis that aberrant reactivation of innate neuronal cell divisions by soluble amyloid-β oligomers is central for the neuron death and cognitive loss associated with Alzheimer’s disease (AD). Prior studies document the essential requirement for soluble forms of tau, which aggregates inside AD neurons to form insoluble neurofibrillary tangles. The signaling pathways involved in this tau-dependent, amyloid-β neuron…

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Closing Remarks

October 7, 2016 @ 11:35 am - 12:00 pm

Lunch – Available to Stay or Go, 2 Riverside Circle: Café/Atrium and Room 210

October 7, 2016 @ 12:00 pm - 1:00 pm
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