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October 2016

Dynamic Regulation of Signaling Pathways in Dopamine Neurons: The Intracellular Actions of Amphetamines, Susan Amara, PhD

October 5, 2016 @ 8:40 am - 9:05 am

Susan Amara, PhD, Scientific Director, Division of Intramural Research Program and Chief, Laboratory of Molecular and Cellular Neurobiology, National Institute of Mental Health, National Institutes of Health -- Neurotransmitter transporters present at the plasma membrane are the primary targets for psychostimulant drugs of abuse and for drugs such as methylphenidate and amphetamines, which are used to treat attention deficit disorders in children. In recent studies we have observed that once amphetamine-like drugs enter dopamine neurons they activate multiple intracellular signaling…

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Genetic Basis of Major Depression – Jonathan Flint, MD

October 5, 2016 @ 9:05 am - 9:30 am

Professor-in-Residence, Department of Psychiatry and Biobehavioral Sciences, UCLA David Geffen School of Medicine
Senior Scientist, Center for Neurobehavioral Genetics, UCLA Semel Institute for Neuroscience and Human Behavior

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A Quantitative Signature of Change in Impulsivity: Toward Prediction of Clinical Response, Warren Bickel, PhD

October 5, 2016 @ 11:00 am - 11:25 am

Warren Bickel, PhD, Virginia Tech Carilion Behavioral Health Research Professor and Professor of Psychology, Virginia Tech-- Predicting response to treatment is an important goal of science and would contribute substantially to precision medicine.  One type of change, referred to as rate (or baseline) dependence, has a quantitative signature that may be exploited to predict who will and will not benefit from an intervention.  Rate dependence refers to an orderly inverse relationship between a baseline measure of behavior and the change…

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Serotonin, Impulsivity, and Cue Reactivity: Preclinical and Clinical Studies, F. Gerard Moeller, MD

October 5, 2016 @ 11:25 am - 11:50 am

 F. Gerard Moeller, MD, Professor, Department of Psychiatry, Pharmacology and Toxicology, and Neurology, Virginia Commonwealth University (VCU); Director, VCU Institute for Drug and Alcohol Studies and Director of Addiction Medicine; Director, C. Kenneth and Dianne Wright Center for Clinical and Translational Research; Associate Vice President for Clinical Research -- Impulsivity has been linked to drug addiction in humans and drug self administration in preclinical models. Likewise, drug cues have been shown to be important in animal and human research. Our…

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Engineering Viral Vectors for Targeted Therapeutics and In Vivo Circuit Connectomics, Tomas Bjorklund, PhD

October 5, 2016 @ 1:00 pm - 1:25 pm

Tomas Bjorklund, PhD, Assistant Professor, Wallenberg Neuroscience Center, Lund University, Lund, Sweden -- In situ neuromodulation has seen significant developments with the rapid recent improvements in optogenetics, chemogenetics and genome editing. However, as these tools progress towards clinical applications, there is an urgent need to develop both the tools to target specific neuronal circuits in the mammalian brain and to dissect circuit function in neurodegenerative and psychiatric disorders. This presentation will share our efforts to develop novel AAV serotypes with targeted tropism, applications…

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A New Approach to Rapid Neurotransmitter Measurement in Humans During Active Cognition, P. Read Montague, PhD

October 5, 2016 @ 1:25 pm - 1:50 pm

P. Read Montague, PhD, Virginia Tech Carilion Vernon Mountcastle Research Professor and Professor of Physics, Virginia Tech --

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SorCS2 Regulates Dopaminergic Wiring and BDNF-Dependent Plasticity, Anders Nykjaer, MD/PhD

October 5, 2016 @ 1:50 pm - 2:15 pm

Anders Nykjaer, MD/PhD, Professor of Medical Biochemistry; Director of the Lundbeck Foundation Research Centre MIND; Danish Research Institute of Translational Neuroscience - DANDRITE; Nordic - EMBL Partnership of Molecular Medicine; Aarhus University, Denmark -- It is well accepted that psychiatric disorders commonly result from developmental deficits superimposed acute changes in synaptic plasticity. Multiple studies have reported association between SORCS2 and ADHD, schizophrenia and bipolar disorder but the underlying molecular mechanism has remained elusive. We find that the receptor SorCS2 exhibits highly…

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