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Insulin Resistance and Neurodegeneration: Novel Mechanisms and Therapeutic Implications, Suzanne Craft, PhD
October 5, 2016 @ 2:45 pm - 3:10 pm
Suzanne Craft, PhD, Professor of Geriatric Medicine, Director, NIA P30 Alzheimer’s Disease Core Center, Co-Director, Sticht Center for Healthy Aging and Alzheimer’s Prevention, Wake Forest University Medical School —
Our knowledge of the multifaceted role of insulin in the central nervous system has expanded rapidly in recent years. It is now apparent that perturbation of this role by insulin resistance and hyperinsulinemia can increase the risk for aging-related neurodegenerative disorders such as Alzheimer’s disease (AD) via effects on a number of mechanistic pathways, delineated in elegant in vitro and animal studies. We have investigated these pathways in humans models using dietary and pharmacologic modulation of insulin sensitivity. We will present results supporting the hypothesis that insulin resistance-associated effects on cerebral glucose metabolism, β-amyloid regulation and inflammation contribute to AD pathophysiology. This premise raises the possibility that treatments aimed at improving or overcoming insulin resistance will benefit patients with AD. We will present data testing this possibility in therapeutic trials using insulin intranasal insulin.