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Synaptic Biomarkers: Promise and Perils for Identifying and Using Them to Optimize Neuronal Health, Greg Valdez, PhD
October 5, 2016 @ 3:10 pm - 3:35 pm
Assistant Professor, VTCRI; Assistant Professor, Virginia Tech School of Biological Sciences, College of Science
The lack of biomarkers is a major roadblock in identifying and testing therapeutics for neurological disorders. In common among neurological diseases is the early and progressive degeneration of synapses, that inevitably cause neuronal dysfunction. Hence, the identification of molecules altered during the earliest phases of synaptic degeneration could serve as potential biomarkers for diagnosing and tracking the progression of neurological disorders. Importantly, they would serve as biological readouts for treatments aimed at slowing, preventing and reversing neuronal dysfunction. In this talk, I will discuss recent advances that should facilitate the discovery of synaptic biomarkers for neurological disorders.