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The Lactate Receptor is Important for Brain Vascularization, Linda Hildegard Bergersen, PhD
October 7, 2016 @ 9:25 am - 9:50 am
Linda Hildegard Bergersen, PhD, Professor, Physiology, University of Oslo, Norway and Professor, Neurobiology of Aging, University of Copenhagen, Denmark —
Cecilie Morland*1,2,3, Krister A. Andersson*1,3, Alena Hadzic1,2,3, Ã˜yvind P. Haugen1, Liv Kleppa1,3, Andreas Gille4, Johanne Egge Rinholm1,3, Elisabeth Holm-Diget1,5, Lauritz H. Kennedy1,3, Tomas StÃ¸len6, Eivind Hennestad7, Yiqing Cai1, Maja Puchades3Â Stefan Offermanns8, Koen Vervaeke7, Ulrik WislÃ¸ff6, Jon Storm-Mathisen3 and Linda H. Bergersen1,3,5
1 The Brain and Muscle Energy Group, and Electron Microscopy Laboratory, Department of Oral Biology, University of Oslo, Oslo, Norway.
2 Institute for Behavioral Sciences, Faculty of Health Sciences, Oslo and Akershus University Collage, Oslo, Norway.
3 The Synaptic Neurochemistry Lab, Division of Anatomy, Department of Molecular Medicine, Institute of Basic Medical Sciences, and Healthy Brain Ageing Centre, University of Oslo, Oslo, Norway.
4 Institute for Experimental and Clinical Pharmacology and Toxicology, Mannheim Medical Faculty, Heidelberg University, Mannheim, Germany.
5 Department of Neuroscience and Pharmacology, and Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
6 Department of Circulation and Medical Imaging, K.G. Jebsen Center of Exercise in Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
7 Laboratory of Neural Computation, Department of Physiology, University of Oslo, Oslo, Norway.
8 Max-Planck-Institute for Heart and Lung Research, Department of Pharmacology, Bad Nauheim, Germany.
* These authors contributed equally to the work
Physical exercise can improve learning and memory and postpone the cognitive decline associated with aging and neurodegenerative disease. Enhanced angiogenesis has been suggested as a key mechanism through which exercise supports brain function. Angiogenesis is stimulated by vascular endothelial growth factor A (VEGFA), but the initial signal that leads to increased cerebral VEGFA in response to exercise has not been determined. I will present our identification of a novel mechanism for regulation of VEGFA and angiogenesis in the brain in response to exercise and that we could also mimic the exercise by injecting L-lactate. The effects of exercise and lactate on VEGFA and angiogenesis were absent in knockout mice lacking the lactate receptor GPR81. The novel mechanism for regulation of VEGFA and angiogenesis in the brain were not found in skeletal muscle. This is the first demonstration that a substance produced in exercising muscle induces supportive effects in brain through an identified receptor.