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Proteomics and CRISPR/Cas Genome Editing Empower Deafness Research, Jung-Bum Shin, PhD
October 6, 2016 @ 1:00 pm - 1:25 pm
Jung-Bum Shin, PhD, Associate Professor of Neuroscience, University of Virginia School of Medicine —
The overall goal of my research is to understand the biology of hearing and the pathobiology of hearing loss. In particular, our focus is the sensory hair cell, the receptor cell of the auditory and vestibular system. I will discuss two present projects:
1) Discovery of novel proteins and genes involved in hearing and deafness: Hair cell mechanotransduction, the process that converts sound-induced mechanical energy into nerve impulses, takes place in a specialized organelle of the hair cell called hair bundle. My lab thus uses a combination of proteomics, protein biochemistry, cell biology and mouse genetics tools to identify novel hair bundle proteins, and to study their role in hearing function.
2) CRISPR-mediated inner ear gene therapy: I will discuss plans and preliminary experiments to apply the CRISPR/Cas technology towards the development of a gene therapy platform for the inner ear.