- This event has passed.
Genetic Basis of Major Depression – Jonathan Flint, MD
October 5, 2016 @ 9:05 am - 9:30 am
Genetic Basis of Major Depression
Jonathan Flint, MD
Professor-in-Residence, Department of Psychiatry and Biobehavioral Sciences, UCLA David Geffen School of Medicine
Senior Scientist, Center for Neurobehavioral Genetics, UCLA Semel Institute for Neuroscience and Human Behavior
Depression is the commonest psychiatric disease and a leading cause of morbidity throughout the world. However our ability to treat depression is limited, with only half of patients responding to pharmacological therapy after three months. Better treatment requires better understanding of the causes of depression. One hope is that a genetic approach will generate clues as to the origins of this common and disabling disorder. However successful genetic analysis of depression has proved much harder than expected. One likely reason is that depression is heterogeneous. I will describe the results of the first successful genome-wide association study of depression. I attribute success to attempts to reduce heterogeneity in the sample.I will present results that support this hypothesis