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Identifying Precise Pharmacological Targets for Aberrant Neuronal Cell Cycle Re-entry in Alzheimer’s Disease, John Lazo, PhD
October 7, 2016 @ 11:10 am - 11:35 am
John Lazo, PhD, Harrison Distinguished Professor, Departments of Pharmacology and Chemistry; Director, Fiske Drug Discovery Lab; University of Virginia —
We are investigating the hypothesis that aberrant reactivation of innate neuronal cell divisions by soluble amyloid-β oligomers is central for the neuron death and cognitive loss associated with Alzheimer’s disease (AD). Prior studies document the essential requirement for soluble forms of tau, which aggregates inside AD neurons to form insoluble neurofibrillary tangles. The signaling pathways involved in this tau-dependent, amyloid-β neuron death are largely unknown. Our goals are to use robust cell platforms to identify the fundamental molecular signaling pathways involved in the cell cycle re-entry process and discover small molecules that could be used with precision to mitigate the subsequent neuronal cell death.