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Identifying Precise Pharmacological Targets for Aberrant Neuronal Cell Cycle Re-entry in Alzheimerâ€™s Disease, John Lazo, PhD
October 7, 2016 @ 11:10 am - 11:35 am
John Lazo, PhD, Harrison Distinguished Professor, Departments of Pharmacology and Chemistry; Director, Fiske Drug Discovery Lab;Â University of VirginiaÂ —
We are investigating the hypothesis that aberrant reactivation of innate neuronal cell divisions by soluble amyloid-Î² oligomers is central for the neuron death and cognitive loss associated with Alzheimerâ€™s disease (AD). Prior studies document the essential requirement for soluble forms of tau, which aggregates inside AD neurons to form insoluble neurofibrillary tangles. The signaling pathways involved in this tau-dependent, amyloid-Î² neuron death are largely unknown. Our goals are to use robust cell platforms to identify the fundamental molecular signaling pathways involved in the cell cycle re-entry process and discover small molecules that could be used with precision to mitigate the subsequent neuronal cell death.