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Serotonin, Impulsivity, and Cue Reactivity: Preclinical and Clinical Studies, F. Gerard Moeller, MD
October 5, 2016 @ 11:25 am - 11:50 am
F. Gerard Moeller, MD, Professor, Department of Psychiatry, Pharmacology and Toxicology, and Neurology, Virginia Commonwealth University (VCU); Director, VCU Institute for Drug and Alcohol Studies and Director of Addiction Medicine; Director, C. Kenneth and Dianne Wright Center for Clinical and Translational Research; Associate Vice President for Clinical Research —
Impulsivity has been linked to drug addiction in humans and drug self administration in preclinical models. Likewise, drug cues have been shown to be important in animal and human research. Our research team has found that serotonin is a link between impulsivity and cue reactivity in preclinical and clinical studies. Specifically, preclinical research has shown that the serotonin (5-HT) 2C receptor (5-HT2CR) agonist lorcaserin reduces impulsivity and cue induced responding for cocaine and oxycodone. Likewise, clinical research has shown that cocaine dependent individuals with a specific 5-HT2CR polymorphism have lower “attentional bias” which is a measure of cue reactivity. Brain connectivity research in humans has shown that the cue related responses are associated with enhanced insular driving of anterior cingulate activity. These results will be discussed related to ongoing research in brain imaging and human self-administration studies.